Our activities in a few keywords
Our research objective: to transform agricultural resources by designing and operating optimised bioprocesses within a context of sustainability.
Our study models
Micro-organisms: bacteria and yeast
Bio-sourced molecules: aroma molecules and synthons
Our general research question
What holistic approach will make it possible to better understand and to control the mechanisms for developing and maintaining biological functionality throughout integrated bio-processes while limiting the environmental impact?
To answer this question, our main objectives are:
- To better understand the mechanisms of development and degradation of target micro-organism functionalities (acidifying activity, cell viability, production performance of molecules of interest, etc.);
- To study biological material through a combination of "omic" approaches - genomics, transcriptomics, proteomics - based on the in-depth knowledge of the metabolic pathways of interest;
- To adapt production conditions (physico-chemical and biotic environment, medium, formulation) and operating conditions, in order to control and optimise the relevant metabolic pathways and, as a consequence, the target functionalities;
- To study new integrated bio-processes involving optimised coupling between upstream (bioconversion, production) and downstream (extraction, purification, stabilisation) processes;
- To take environmental impact criteria into account at the process level (e.g., fermentation substrates and solvents used, water and energy consumption), associated with the development and preservation of functionalities in order to propose alternative sustainable technologies.
Projects supported by public funding
Project FP7 CAFE (222654-2) « Computer aided food processes for control engineering ». http://www.cafe-project.org/
CellExtraDry Carnot-Qualiment project: Preserving the functionality of antioxidant-enriched yeast.
ADEME MIDIPER, project financed within the framework of the AAP Bioressources Industries Performances (co-construction and participation), "Study of the technical and financial feasibility of a MIni DIstillery close to resources and needs, equipped with a membrane dehydration system based on PERmeation".
LacLys ANR project (ANR-07-PNRA-0010): "Lactalbumin Lysozyme: Stabilisation of supramolecular structures by lyophilisation (participation, coordinator: S. Bouhallab, STLO, Rennes).
AliminTest ANR project (ANR-06-PNRA-0024) (participation, coordinator: R. Nalin), "Impact of diet on the structural and functional dynamics of the human intestinal microbiota".
VDQA ANR project (ANR-05-PNRA-0011) (co-construction, participation, coordinators: M. Bes and J.L. Escudier, UE Pech Rouge), "Quality wine with low alcohol content".
Examples of industrial contracts
Partnership with the French National Dairy Industry Council(CNIEL), DEPhy project: "Characterisation of the physiological state of cells from culture to stabilisation for diversifying and optimising starter production".
Partnership with BioProx, OSEO project: "Improving freeze-dried lactic acid bacteria by modifying formulation and freeze-drying operating conditions".
Partnership with Lallemand SAS, "Improving the biological stability of lactic acid starters by modulating fermentation conditions"
Partnership with Les Grands Moulins de Paris, "Production of lactic acid bacteria capable of producing exopolysaccharides for making liquid starters for dough manufacture".
Partnership with Naturatech, "Improving the conservation of lactic acid starters (viability and biological activity)"
Partnership with Bongrain SA, "Study of technical feasibility of coupling fermentation and separation for lactic acid recovery"
Members of BioMiP team can be contacted:
- by phone: +33 (0)1 30 81 + extension (click on member name)
- by e-mail: firstname.lastname@example.org
Violaine Athès (Scientific coordinator)
Vincent Monclus (Engineer)
Fernanda Fonseca (Scientific coordinator)